https://jctei.com/index.php/jctei <p>The <strong>“Journal of Clinical Trials and Experimental Investigations (Abbreviation: J Clin Trials Exp Investig)" (e-ISSN 2822-5090)</strong> is an independent, quarterly, peer-reviewed, double-blind, open-access international general medical journal founded in January 2022. It is published four times a year (March, June, September, and December). This journal publishes Original Articles, Reviews, Short communications, Case reports, Letters to the Editor, Opinion papers, Technical notes, and Editorials. Articles are selected and published following a rigorous analysis, according to internationally accepted standards. The journal is open to scholars, as well as all members of the medical community, expressing interest in using this forum to publish their work. No fee is charged from the authors during the article evaluation and publication process. The Journal of Clinical Trials and Experimental Investigations is the official journal of the Silvan Academy of Surgery. The journal is non-profit and doesn't accept advertisements. The official language is English.</p> Unico's medicine en-US Journal of Clinical Trials and Experimental Investigations 2822-5090 <p><img src="https://www.jctei.com/index.php/jctei/management/settings/public/site/images/by-nc-lisans.png" alt="" width="114" height="40" /> The journal is licensed under a <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank" rel="license noopener">Attribution4.0 International (CC BY 4.0)</a>.</p> https://jctei.com/index.php/jctei/article/view/158 <p><strong>Objective:</strong> Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibroinflammatory disorder affecting multiple organ systems, often requiring imaging for diagnosis and monitoring. Despite its critical role, an optimal imaging strategy, including modality preference and follow-up intervals, remains undefined. This study evaluates the utilization patterns of different imaging modalities in IgG4-RD.</p> <p><strong>Materials and methods:</strong> This retrospective, single-center study included 18 patients diagnosed with IgG4-RD according to ACR/EULAR criteria between May 2020 and December 2024. Clinical, laboratory, histopathological, and imaging data were collected. Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET-CT) were analyzed for diagnostic and follow-up trends. Patients were stratified based on the presence of acute kidney injury (AKI) at diagnosis.</p> <p><strong>Results:</strong> At diagnosis, CT (83.3%) was the most frequently used modality, followed by PET-CT (61.1%) and MRI (27.8%). Combined imaging was performed in 66.6% of cases initially but declined during follow-up. The choice of the first follow-up imaging differed between patients with and without AKI (p=0.072). Notably, follow-up imaging intervals were significantly shorter in AKI patients (30.5 vs. 49 months, p=0.049). Over time, PET-CT use decreased, while MRI became the preferred modality. Despite these variations, no standardized follow-up approach was observed.</p> <p><strong>Conclusion:</strong> Our findings indicate a shift from multimodal to single-modality imaging during follow-up, with variations based on AKI status. The lack of a standardized imaging protocol indicates the need for consensus guidelines to enhance disease monitoring and optimize patient outcomes.</p> Rabia Deniz Cemal Bes Copyright (c) 2025 Journal of Clinical Trials and Experimental Investigations https://creativecommons.org/licenses/by/4.0 2025-03-19 2025-03-19 4 1 1 6 10.5281/zenodo.15069860