Diagnostic Value of The Ischemia Modified Albumin and Pentraxin 3 In Pediatric Appendicitis: A Meta Analysis

Diego Falchi; Ayten Ceren Bakır; Toni Risteski; Hani Abu Tziam; Seçil Yüksel; Sena Inal Azizoğlu

doi:10.5281/zenodo.6857498

Authors

Diego Falchi University of Sassari, Faculty of Medicine, General Medicine and Practitioner, Sassari, Italy
Ayten Ceren Bakır Marmara University, Faculty of Medicine, Department of Pediatric Surgery, Istanbul, Turkey
Toni Risteski University Clinic for Pediatric Surgery, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, N Macedonia
Hani Abu Tziam Department of Family Medicine, Clalit City, Lod, Israel
Seçil Yüksel Başakşehir Çam and Sakura City Hospital, Department of Pediatric Surgery, Istanbul, Turkey
Sena Inal Azizoğlu Başakşehir Çam and Sakura City Hospital, Department of Pediatrics, Istanbul, Turkey

DOI:

https://doi.org/10.5281/zenodo.6857498

Keywords:

Ischemia Modified Albumin, Pentraxin 3, Pediatric, Appendicitis

Abstract

Objective: In this meta-analysis, we aimed to review the diagnostic value of pentraxin 3 (PTX3) and ischemia-modified albumin (IMA) biomarkers in pediatric appendicitis.

Method: Studies focusing on the value of PTX3 and IMA in the diagnosis of appendicitis were searched related to the PubMed database. Only randomized prospective clinical trials were included in this study.

Results: After the screening, 6 articles based on the diagnostic value of IMA in appendicitis and 5 articles on the diagnostic value of PTX3 were reviewed. A total of 5 studies were included. The data of the 385 patients were reviewed. Sensitivity of PTX3 was 73-92% and specificity 88-100%, while IMA sensitivity was 89-96.7% and specificity was 26-99.7% in acute appendicitis.

Conclusion: Although the results of the present study indicate that PTX3 and IMA can be shown as biomarkers in the differential diagnosis of acute abdomen, further study is needed to determine the cut-off value.

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