Instructions for Authors

The “Journal of Clinical Trials and Experimental Investigations (Abbreviation: J Clin Trials Exp Investig)" (e-ISSN 2822-5090) is an independent, quarterly, peer-reviewed, double-blind, open-access international general medical journal founded in January 2022. It is published four times a year (March, June, September, and December). This journal publishes Original Articles, Reviews, Short communications, Case reports, Letters to the Editor, Opinion papers, Technical notes, and Editorials. Articles are selected and published following a rigorous analysis, according to internationally accepted standards. The journal is open to scholars, as well as all members of the medical community, expressing interest in using this forum to publish their work. The official language is English. Its spaces are open to scholars, as well as all members of the medical community expressing interest in using this forum to publish their work, in compliance with the editorial policies mentioned below.

JCTEI is published four times a year and receives original manuscripts which, upon being accepted by the Editorial Committee, cannot be published partially or in full elsewhere without the consent of JCTEI. All works submitted must adhere to the format described below and will be subject to review by experts and the Editorial Committee to determine their acceptance.

The main purpose of JCTEI is to publish original works from the broad field of medicine, as well as provide up-to-date and relevant information to the national health area.
To this end, JCTEI will consider contributions in the following sections:

-Editorial (only by invitation)
-Original article
-Review article
-Clinical case
-Letter to the editor

Manuscripts must be uploaded in electronic form through the new editorial system,  where the author for correspondence should register as the author of the article. Once this author has obtained an username and password, the documents should be uploaded following the instructions.

All articles must include, without exception, title, name and surname(s) of each author (without titles or positions), affiliation, name and address of the correspondence author, the complete manuscript text, tables and figures. The contributions of the authors should be noted as follows:

-Research concept and design:
-Data analysis and interpretation:
-Collection and/or assembly of data:
-Writing the article:
-Critical revision of the article:
-Final approval of the article:

All texts should be written and submitted in Microsoft Word format with double-spaced, Times new roman 12. All manuscripts must be correctly written in English (for manuscripts that are written in Italian, Spanish, Portuguese, French, German, Turkish, Arabic, and Kurdish, we would like to declare that we provide a free translation into English) The pages will be numbered consecutively, and the number will be placed on the top of every page.

Original articles, review articles, report cases and articles regarding methods and techniques in Radiology should include a first page with all personal data, a full manuscript file completely anonymous and the declarations of conflict of interest, funding and ethical responsibilities that the author can fill in electronically when submitting the article.

The front page must show the title of the work in English and a short title with less than 40 characters (counting letters and spaces); the authors' names and ORCID number (without titles or academic degrees); their institution of registration (affiliations); email address and full name of the corresponding author; acknowledgments and the funding if exists.

The full manuscript file should be completely anonymous and include the summary in English, the full text of the manuscript, references, tables, and figures footnotes.

For more information about manuscript preparation, we suggest consulting the website of Uniform Requirements for Manuscripts Submitted to Biomedical Journals ( For further details: International Committee of Medical Journal Editors (

Authors are required to suggest 4 potential reviewers with information of institutional and e-mail address. At least 2 of the potential reviewers suggested should be from a different country to the corresponding authors. The Editors reserve the right to indicate these or other reviewers for manuscript evaluation.


ORCiD IDs of the corresponding author and other authors must be submitted during the registration process. This section is mandatory.

The collection of ORCID iDs from corresponding authors is now part of the submission process of this journal. If you already have an ORCID iD you will be asked to associate that to your submission during the online submission process. We also strongly encourage all co-authors to link their ORCID ID to their accounts in our online peer review platforms. It takes seconds to do: click the link when prompted, sign into your ORCID account and our systems are automatically updated. Your ORCID iD will become part of your accepted publication’s metadata, making your work attributable to you and only you. Your ORCID iD is published with your article so that fellow researchers reading your work can link to your ORCID profile and from there link to your other publications.

If you do not already have an ORCID iD please follow this link to create one.

This summary will be presented in a maximum of 350 words. It will begin with an English language version of the title. It will also contain 3 to 6 keywords. Abstract should be written under subheading as: objective, materials and methods, results, and conclusions.

The abstract should be followed by 3–6 keywords written in the language of the manuscript and recommended by the Index Medicus Subject Headings (MeSH).

It must include background information, the approach to the problem, and the purpose of the study, all clearly worded and well supported by the bibliography reviewed.

Material and methods
The characteristics of the sample and the methods used, with relevant references, will be clearly marked so that reading of this chapter allows similar studies to be conducted by other researchers. The statistical methods used must be clearly marked with their corresponding reference. The authors must detail in this section the ethical procedures followed; necessary for experiments with animals, patients, confidential data management, informed consent, etc. And that they have obtained the corresponding authorization by the ethics committee of their institution.

The main findings of the study must be included and may be compared only with figures or graphics which are strictly necessary and are intended to extend the information contained in the text.

The results must be contrasted with the information reported in the literature, and with the objectives and hypotheses expressed in the work.

In this section, authors must summarize the main conclusions of their study and the future recommended studies in case conclusions are preliminary. Conclusions should be in agreement with the objectives of the study and they should be directly originated from the reported results.

This section will contain acknowledgments to individuals and institutions, as well as financing sources. This section belongs to the first front page in order for the main text file to remain anonymous.

We use Vancouver reference style. These will be presented in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (International Committee of Biomedical Journal Editors). References will be marked with consecutive numerals, sorted in the order in which they first appear in the text. They will be referred to in the text, tables, and figure footnotes with the corresponding numbers. In quotations with multiple authors (more than six authors), only the first 6 authors of the work must be included, followed by et al., after the abbreviation of the name/s of the 6th author. In case of 6 or fewer authors, all 6 must be included in the quotation (

-Articles published in periodic journals must appear in the following format: Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, et al. Recombinant human leptin in hypothalamic Women with amenorrhea. N Engl J Med. 2004;351(10):987-97.

-References to books must include the name of the publisher, as well as the city and country of publication, and the year of publication, in accordance with the following model: Aréchiga H, Somolinos J. Contribuciones mexicanas a la medicina moderna. México, D.F.: Fondo de Cultura Económica; 1994.

-References to chapters in books must appear as follows: Pasternak RC, Braunwald E. Acute myocardial infarction; or: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL, eds. Harrison's Principles of Internal Medicine. 12.a ed. Nueva York: mcgraw-Hill Inc.; 1994., pp. 1066-77.

Always use the standard abbreviation of a journal’s name according to the ISSN List of Title Word Abbreviations, see

They must be double-spaced and consecutively numbered, in the order quoted in the text, with the titles in the top and the meaning of abbreviations as well as explanatory notes in the footer. They must be included at the end of the manuscript, after the references section.

Figures or graphs
Figure footnotes must be written double-spaced. The footer must contain the information needed to correctly interpret the figure without resorting to the text. The text must reference them in order. Qualities: The graphics, layouts, and drawings must be generated in high-resolution graphics programs (JPG, TIFF, EPS, PowerPoint and Illustrator). All iconography must be original. Where this is not the case, the source reference must be quoted, and the author must obtain the prior permission of the relevant publisher. In the figures, data already written in the text will not be repeated. Photographs of objects must include a rule to calibrate the reference measurements. In microphotographs, the microscopic magnification or reference micron bar must appear. The patient's name, face, data, or any other recognizable feature will not be shown in the figures. We suggest that authors add color illustrations that adequately enrich the text. 

Ethical responsibilities
With regard to potential conflicts of interest, individual right to privacy and data confidentiality, as well and human and animal rights, the journal adheres to the latest version of the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (formerly the Uniform Requirements for Manuscripts) published by the International Committee of Medical Journal Editors, found at Copies will be required of informed consent forms in the case of studies in patients and clinical cases, and of the letter from the Independent Ethics Committee of the corresponding institution in the case of clinical and experimental studies (For more please see )

The authors must mention all organizations that funded their research in the Funding section of your submission, including grant numbers where appropriate.

Conflict of interests
Authors must describe any financial or personal relationship with any other person or organization which can cause a conflict of interest regarding this article.

Types of articles

This section will be devoted to the analysis and consideration of the population's health problems, the different preventive and therapeutic approaches, and the advances achieved in the field of biomedical research. Editorials will only be accepted by invitation from the Editor. Maximum length for Editorials will be 5 pages and 5 references.

Original article
Original articles present results from clinical or basic original research. The full manuscript text should be structured in: Introduction, Materials and methods, Results, Discussion, and Conclusions. The maximum length for Original Articles will be 20 pages, 8 figures, 8 tables, and 50 references. 

Review article
They will treat a current topic that is medically relevant. The main author or the relevant individual must be an authority in the reviewed area or subject, and that person must attach a bibliography of his/her contributions supporting his/her experience in the subject. Maximum length will be 20 pages, 8 figures, 8 tables, and 100 references.

Clinical case
Clinical cases present details of real patient cases from medical or clinical practice. They must be comprised of free-form summaries in English (100 words maximum), introduction, case presentation, discussion, conclusions, and bibliography. Maximum length 10 pages, 6 figures, 6 tables, and 30 references. No Ethical form is asked for case reports.

Letter to the editor
These are open forum for personal opinions related to medical topics or to previously published articles in our journal. They will have a maximum length of one page, 2 figure, 2 table, and 5 bibliographical references. No Ethical form is asked for letter to the Editor.


Authors who publish with this journal agree to the following terms:

certify that they qualify for authorship because of their substantial contribution to the work submitted. The authors undersigned declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. The authors agree to transfer the copyright to the Journal of Clinical Trials and Experimental Investigations to be effective if and when the manuscript is accepted for publication. Authors agree to the published study licensed under Attribution 4.0 International (CC BY 4.0).

Archiving and repository
The full text of all articles is deposited in CLOCKSS,  LOCKSS and PKP Preservation Network (PN) around the world to guarantee long-term digital preservation. It permits those libraries to create permanent journal archives for preservation and restoration. Submitting an article through the website starts the submission/evaluation process for publication. The journal has a policy allowing authors to deposit versions of their work in JCTEI repository services ( 

In addition, when preparing the manuscript, it is obligatory to consider the structure of the article according to one of the checklists below:

-CONSORT checklist for clinical trials
-STROBE checklist for observational studies
-CASP checklist for qualitative studies
-PRISMA checklist for reviews
-or other suggested by EQUATOR

English language editing
For editors and reviewers to accurately assess the work presented in your manuscript you need to ensure the English language is of sufficient quality to be understood. If you need help with writing in English you should consider:

-Getting a fast, free online grammar check.
-Ask a colleague who is proficient in English to review your manuscript for clarity.
-Visiting the English language tutorial which covers the common mistakes when writing in English.
-Using a professional language editing service where editors will improve the English to ensure that your meaning is clear and identify problems that require your review.

Free online grammar check
English language tutorial
Nature Research Editing Service
American Journal Experts

Please note that the use of a language editing service is not a requirement for publication in this journal and does not imply or guarantee that the article will be selected for peer review or accepted. If your manuscript is accepted it will be checked by our copyeditors for spelling and formal style before publication.

Works must be uploaded in electronic form at the following URL: An electronic return receipt will be issued to the author, and the opinion of the Editor shall be communicated in a timely manner.