The treatment of hyperthyroidism with methimazole in a pregnant who developed agranulocytosis due to propylthiouracil




Agranulocytosis, graves disease, methimazole, pregnant women, propylthiouracil


The most common cause of hyperthyroidism during pregnancy is Graves' disease. Anti-thyroid drugs are primarily used in the treatment of pregnant women with Graves’ disease. Anti-thyroid drugs’ side effects include itching, jaundice, skin rash, drug fever, arthralgia, lupus-like syndrome, toxic hepatitis, vasculitis, hypergammaglobulinemia, and lymphadenopathy.  Although agranulocytosis, a serious side effect of anti-thyroid drugs, is rare, it is difficult to treat when it occurs during pregnancy. In this article, we aimed to present a pregnant case with Graves' disease who developed agranulocytosis after the initiation of propylthiouracil, whose agranulocytosis was treated with granulocyte colony-stimulating factor, and subsequently, hyperthyroidism was treated with methimazole without any problem.


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How to Cite

Mamiş MS, Uyar N, Eren MA, Sabuncu T. The treatment of hyperthyroidism with methimazole in a pregnant who developed agranulocytosis due to propylthiouracil. J Clin Trials Exp Investig [Internet]. 2022 Sep. 30 [cited 2024 Jul. 24];1(2):56-9. Available from: