The treatment of hyperthyroidism with methimazole in a pregnant who developed agranulocytosis due to propylthiouracil

Mehmet Selim Mamiş; Nida Uyar; Mehmet Ali Eren; Tevfik Sabuncu

doi:10.5281/zenodo.7130554

Authors

Mehmet Selim Mamiş Harran University, Faculty of Medicine, Department of Internal Medicine, Sanliurfa, Turkey https://orcid.org/0000-0003-0245-3321
Nida Uyar Harran University, Faculty of Medicine, Department of Endocrinology, Sanliurfa, Turkey https://orcid.org/0000-0002-5904-8178
Mehmet Ali Eren Harran University, Faculty of Medicine, Department of Endocrinology, Sanliurfa, Turkey https://orcid.org/0000-0002-3588-2256
Tevfik Sabuncu Harran University, Faculty of Medicine, Department of Endocrinology, Sanliurfa, Turkey https://orcid.org/0000-0001-6504-5355

DOI:

https://doi.org/10.5281/zenodo.7130554

Keywords:

Agranulocytosis, graves disease, methimazole, pregnant women, propylthiouracil

Abstract

The most common cause of hyperthyroidism during pregnancy is Graves' disease. Anti-thyroid drugs are primarily used in the treatment of pregnant women with Graves’ disease. Anti-thyroid drugs’ side effects include itching, jaundice, skin rash, drug fever, arthralgia, lupus-like syndrome, toxic hepatitis, vasculitis, hypergammaglobulinemia, and lymphadenopathy. Although agranulocytosis, a serious side effect of anti-thyroid drugs, is rare, it is difficult to treat when it occurs during pregnancy. In this article, we aimed to present a pregnant case with Graves' disease who developed agranulocytosis after the initiation of propylthiouracil, whose agranulocytosis was treated with granulocyte colony-stimulating factor, and subsequently, hyperthyroidism was treated with methimazole without any problem.

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