Comparison of LIFT and cutting seton methods in the treatment of high transsphincteric anal fistulas

Authors

DOI:

https://doi.org/10.5281/zenodo.17282761

Keywords:

Ligation of intersphincteric fistula tract, Cutting seton, Anal fistula

Abstract

Objective: Many treatment modalities have been recommended for high transsphincteric anal fistulas, but none have been proven to be ideal. This study aims to compare the ligation of intersphincteric fistula tract (LIFT) and cutting seton methods in the treatment of high transsphincteric anal fistulas.

Materials and methods: This study was conducted in the general surgery department of Health Sciences University Gazi Yaşargil Training and Research Hospital. Retrospective data of patients who underwent surgery for perianal fistula in our clinic were reviewed. Patients diagnosed with high transsphincteric anal fistulas were included in the study. According to the treatment method, patients were categorized into two groups: LIFT (Group 1) and cutting seton (Group 2). The groups were compared in terms of recovery time, recurrence rate, postoperative pain, and incontinence.

Results: There were a total of 60 patients in the study, with 30 patients in each group.  The mean recovery time was significantly shorter in Group 1. At the end of 1-year follow-up, successful results were obtained in 21 (70%) patients in Group 1 and in 24 (80%) patients in Group 2 (p=0.371). While there was no significant difference between the groups in the visual analog scale evaluation in the preoperative period (p=0.398), there were significantly higher pain scores in Group 2. There was no difference between the two groups in the Wexner score at preoperative, postoperative 4th and 12th weeks.

Conclusion: Both LIFT and cutting seton procedures exhibit similar long-term healing, recurrence, and continence preservation rates in patients with high transsphincteric anal fistulas. However, LIFT has the advantage of less postoperative pain and shorter recovery time.

References

Ho YH, Tan M, Leong AF, Seow-Choen F. Marsupialization of fistulotomy wounds improves healing: a randomized controlled trial. Br J Surg. 1998;85(1):105-7.

Theerapol A, So BY, Ngoi SS. Routine use of setons for the treatment of anal fistulae. Singap Med J. 2002;43(6):305-7.

Maralcan G, Başkonuş I, Gökalp A, Borazan E, Balk A. Long-term results in the treatment of fistula-in-ano with fibrin glue: a prospective study. J Korean Surg Soc. 2011;81(3):169-75.

Buchanan GN, Bartram CI, Phillips RK, Gould SW, Halligan S, Rockall TA, et al. Efficacy of fibrin sealant in the management of complex anal fistula: a prospective trial. Dis Colon Rectum. 2003;46(9):1167-74.

McGee MF, Champagne BJ, Stulberg JJ, Reynolds H, Marderstein E, Delaney CP. Tract length predicts successful closure with anal fistula plug in cryptoglandular fistulas. Dis Colon Rectum. 2010;53(8):1116-20.

Schwandner T, Roblick MH, Kierer W, Brom A, Padberg W, Hirschburger M. Surgical treatment of complex anal fistulas with the anal fistula plug: a prospective, multicenter study. Dis Colon Rectum. 2009;52(9):1578-83.

Champagne BJ, O'Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN. Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum. 2006;49(12):1817-21.

Jarrar A, Church J. Advancement flap repair: a good option for complex anorectal fistulas. Dis Colon Rectum. 2011;54(12):1537-41.

Ho KS, Ho YH. Controlled, randomised trial of island flap anoplasty for treatment of trans-sphincteric fistula-in-ano: early results. Tech Coloproctol. 2005;9(2):166-8.

Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K. Total anal sphincter saving technique for fistula-in-ano; the ligation of intersphincteric fistula tract. J Med Assoc Thai. 2007;90(3):581-6.

Bleier JI, Moloo H, Goldberg SM. Ligation of the intersphincteric fistula tract: an effective new technique for complex fistulas. Dis Colon Rectum. 2010;53(1):43-6.

Tan KK, Tan IJ, Lim FS, Koh DC, Tsang CB. The anatomy of failures following the ligation of intersphincteric tract technique for anal fistula: a review of 93 patients over 4 years. Dis Colon Rectum. 2011;54(11):1368-72.

Wallin UG, Mellgren AF, Madoff RD, Goldberg SM. Does ligation of intersphincteric fistula tract raise the bar in fistula surgery? Dis Colon Rectum. 2012;55(11):1173-8.

Lehmann JP, Graf W. Efficacy of LIFT for recurrent anal fistula. Colorectal Dis. 2013;15(5):592-5.

Liu WY, Aboulian A, Kaji AH, Kumar RR. Long-term results of ligation of intersphincteric fistula tract (LIFT) for fistula-in-ano. Dis Colon Rectum. 2013;56(3):343-7.

Aboulian A, Kaji AH, Kumar RR. Early result of ligationof the intersphincteric fistula tract for fistula-in-ano. Dis Colon Rectum. 2011;54(3):289-92.

Alsari S, Kim NK. Overview of anal fistula and systematic review of ligation of the intersphincteric fistula tract (LIFT). Tech Coloproctol. 2013;18(1):13–22.

Yassin NA, Hammond TM, Lunniss PJ, Phillips RK. Ligation of the intersphincteric fistula tract in the management of anal fistula. A systematic review. Colorectal Dis. 2013;15(5):527-35.

Matos D, Lunniss PJ, Phillips RKS. Total sphincter conservation in high fistula in ano: results of a new approach. Br J Surg. 1993;80(6):802-4.

Shanwani A, Nor AM, Amri N. Ligation of the intersphincteric fistula tract (LIFT): a sphincter-saving technique for fistula-in-ano. Dis Colon Rectum. 2010;53(1):39-42.

Malakorn S, Sammour T, Khomvilai S, Chowchankit I, Gunarasa S, Kanjanasilp P, et al. Ligation of Intersphincteric Fistula Tract for Fistula in Ano: Lessons Learned From a Decade of Experience. Dis Colon Rectum. 2017;60(10):1065-70.

Malik AI, Nelson RL. Surgical management of anal fistulae: a systematic review. Colorectal Dis. 2008;10(5):420-30.

Hamalainen KP, Sainia AP. Cutting seton for anal fistulas: high risk of minor control defects. Dis Colon Rectum. 1997;40(12):1443-6.

Mc Courtney JS, Finlay IG. Cutting seton without preliminary internal sphincterotomy in managenment of complex high fistula in ano. Dis Colon Rectum. 1996;39(1):55-8.

Lykke A, Stendahl J, Wille PA. Treating high anal fistula with slow cutting. Ugeskr Laeger. 2010;172(7):516-9.

Kamrava A, Collins JC. A decade of selective use of adjustable cutting seton combined with fistulotomy for anal fistula. Am Surg. 2011;77(10):1377-80.

Ritchie RD, Sackier JM, Hodde JP. Incontinence rates after cuttingseton treatment for anal fistula. Colorectal Dis. 2009;11(6):564-71.

Downloads

Published

2025-09-30

How to Cite

1.
Demiroglu O, Ofkeli O, Gundes E, Halicioglu I, Ayaydin VE, Tuzun A. Comparison of LIFT and cutting seton methods in the treatment of high transsphincteric anal fistulas. J Clin Trials Exp Investig [Internet]. 2025 Sep. 30 [cited 2025 Oct. 12];4(3):127-35. Available from: https://jctei.com/index.php/jctei/article/view/170