Plasmacytoma: A Rare Case of Bone Malignancy

Authors

  • Medine Dicleli Dicle University Faculty of Medicine, Department of Pathology Diyarbakır, Turkey.
  • Ulaş Alabalık Dicle University Faculty of Medicine, Department of Pathology Diyarbakır, Turkey.
  • Tuğçem Bıçak Dicle University Faculty of Medicine, Department of Pathology Diyarbakır, Turkey.
  • Gülden Yıldız Kafkas University Faculty of Medicine, Department of Pathology Kars, Turkey
  • Hatice Sertakan Dicle University Faculty of Medicine, Department of Pathology Diyarbakır, Turkey.
  • Mustafa Nacir Muş State Hospital Department of Patghology, Muş, Turkey

DOI:

https://doi.org/10.5281/zenodo.6857825

Keywords:

Plasmacytoma, Histopathology, Plasma cell

Abstract

Solitary Plasmacytoma is a rare disease characterized by a localized proliferation of neoplastic monoclonal plasma cell, without evidence of systemic disease. It can be subdivided into solitary bone plasmacytoma if the lesion originates in bone, or solitary extramedullary plasmacytoma if the lesion involves a soft tissue. A 25-year-old male patient is admitted to our clinic with hip pain. In the biopsy performed from the left iliac bone, atypical cells with rounded nuclei, granular chromatin and eccentrically located, extensive cytoplasm, and plasma cell morphology were observed. Because of CD38 positivity and plasma cell morphology, kappa lambda examination performed by CISH showed kappa positive lambda negative. Plasmocytomas are easily recognizable on tissue sections if the plasma cells are not poorly differentiated (plasmoblastic or anaplastic). In poorly differentiated lesions, immunohistochemical staining or in situ hybridization studies of kappa and lambda light chains can be performed.

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Published

2022-07-20

How to Cite

1.
Dicleli M, Alabalık U, Bıçak T, Yıldız G, Sertakan H, Nacir M. Plasmacytoma: A Rare Case of Bone Malignancy . J Clin Trials Exp Investig [Internet]. 2022 Jul. 20 [cited 2024 Mar. 29];1(1 March-June):17-21. Available from: https://jctei.com/index.php/jctei/article/view/4