Lichenoid drug eruption due to pirfenidone in a patient with idiopathic pulmonary fibrosis

Mehmet Semih Celik; Candan Celik; Nagehan Cepik; Mehmet Selcuk Ozercan

doi:10.5281/zenodo.13830529

Authors

Mehmet Semih Celik Firat University Hospital, Department of Dermatology, Elazig, Turkey. https://orcid.org/0000-0002-3378-0619
Candan Celik Firat University Hospital, Department of Dermatology, Elazig, Turkey https://orcid.org/0009-0008-6759-388X
Nagehan Cepik Firat University Hospital, Department of Dermatology, Elazig, Turkey https://orcid.org/0009-0006-1409-250X
Mehmet Selcuk Ozercan Firat University Hospital, Department of Pathology, Elazig, Turkey https://orcid.org/0009-0008-8507-7600

DOI:

https://doi.org/10.5281/zenodo.13830529

Keywords:

Idiopathic pulmonary fibrosis, lichenoid drug eruption, pirfenidone

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarring in the lung parenchyma, leading to decreased quality of life and early mortality. Pirfenidone and nintedanib have been approved for the treatment of IPF based on their ability to slow functional decline and disease progression. Lichenoid drug eruption (LDE) refers to a drug-induced eruption resembling lichen planus, typically presenting as purple, symmetrical, eczematous plaques. While skin reactions due to pirfenidone have been reported in numerous cases, pirfenidone-induced LDE is rarely observed. In this case, we present a rare instance of pirfenidone-induced LDE.

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