The relationship between social media addiction, inflammation, Dopamine, and awareness in adult patients with acne vulgaris

Mehmet Semih Celik; Mehmet Can Cepik

doi:10.5281/zenodo.14550109

Authors

Mehmet Semih Celik Bismil State Hospital, Department of Dermatology, Diyarbakir, Turkey https://orcid.org/0000-0002-3378-0619
Mehmet Can Cepik Firat University Hospital, Department of Psychiatry, Elazig, Turkey https://orcid.org/0009-0002-4844-915X

DOI:

https://doi.org/10.5281/zenodo.14550109

Keywords:

Acne vulgaris, awareness, dopamine, inflammation

Abstract

Objective: The aim of this study is to explore the relationship between social media addiction, inflammation, dopamine levels, and awareness in adult patients with acne vulgaris, considering psychological and physiological aspects.

Material and methods: A total of 98 participants were included in the study: 53 acne patients (23 male, 30 female) and 45 control group members (20 male, 25 female). Both the case and control groups consisted of non-smokers and individuals who were not addicted to alcohol or gambling. The patient group was divided into three subgroups (mild, moderate, and severe) based on the International Global Acne Grading System (IGA). All participants were administered the 6-item Bergen Social Media Addiction Scale (BSMAS), and according to the results, they were classified into four groups: mild, moderate, high, and very high addiction.

Results: The addiction level of the case group was observed as moderate with a score of 14.0±4.45, while the addiction level of the control group was observed as high with a score of 21.0±5.20. A significant difference was found between the two groups (p<0.001).

Conclusion: We attribute the lower level of addiction in acne patients compared to the healthy control group to a decrease in dopamine activation secondary to inflammation and to the state of awareness. However, it is clear that this issue requires further detailed research.

References

Vasam M, Korutla S, Bohara RA. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology-based advances. Biochem Biophys Rep. 2023;36:101578.

Thomas DR. Psychosocial effects of acne. J Cutan Med Surg. 2004;8(4):3-5.

Cheng C, Lau YC, Chan L, Luk JW. Prevalence of social media addiction across 32 nations: Meta-analysis with subgroup analysis of classification schemes and cultural values. Addict Behav. 2021;117:106845.

Cheng C, Wang HY, Sigerson L, Chau CL. Do the socially rich get richer? A nuanced perspective on social network site use and online social capital accrual. Psychol Bull. 2019;145(7):734-64.

Duradoni M, Innocenti F, Guazzini A. Well-Being and Social Media: A Systematic Review of Bergen Addiction Scales. Future Internet. 2020;12(2):24.

Firlej E, Kowalska W, Szymaszek K, Roliński J, Bartosińska J. The Role of Skin Immune System in Acne. J Clin Med. 2022;11(6):1579.

Dréno B, Bettoli V, Araviiskaia E, Sanchez Viera M, Bouloc A. The influence of exposome on acne. J Eur Acad Dermatol Venereol. 2018;32(5):812-9.

Jugeau S, Tenaud I, Knol AC, Jarrousse V, Quereux G, Khammari A, et al. Induction of toll-like receptors by Propionibacterium acnes. Br J Dermatol. 2005;153(6):1105-13.

Ozlu E, Karadag AS, Ozkanli S, Oguztuzun S, Kilic M, Zemheri E, et al. Comparison of TLR-2, TLR-4, and antimicrobial peptide levels in different lesions of acne vulgaris. Cutan Ocul Toxicol. 2016;35(4):300-9.

Kelhälä HL, Palatsi R, Fyhrquist N, Lehtimäki S, Väyrynen JP, Kallioinen M, et al. IL-17/Th17 Pathway Is Activated in Acne Lesions. PLOS ONE. 2014;9(8):e105238.

Fujiwara H, Tsurumi K, Shibata M, Kobayashi K, Miyagi T, Ueno T, et al. Life Habits and Mental Health: Behavioural Addiction, Health Benefits of Daily Habits, and the Reward System. Front Psychiatry. 2022;13:813507.

Felger JC, Miller AH. Cytokine Effects on the Basal Ganglia and Dopamine Function: the Subcortical Source of Inflammatory Malaise. Front Neuroendocrinol. 2012;33(3):315-27.

Belevych N, Buchanan K, Chen Q, Bailey M, Quan N. Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation. Brain Behav Immun. 2010;24(7):1137-47.

Kitagami T, Yamada K, Miura H, Hashimoto R, Nabeshima T, Ohta T. Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier. Brain Res. 18 Temmuz 2003;978(1-2):104-14.

Felger JC, Alagbe O, Hu F, Mook D, Freeman AA, Sanchez MM, et al. Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression. Biol Psychiatry. 2007;62(11):1324-33.

Capuron L, Pagnoni G, Drake DF, Woolwine BJ, Spivey JR, Crowe RJ, et al. Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration. Arch Gen Psychiatry. 2012;69(10):1044-53.

Neurauter G, Schröcksnadel K, Scholl-Bürgi S, Sperner-Unterweger B, Schubert C, Ledochowski M, et al. Chronic immune stimulation correlates with reduced phenylalanine turnover. Curr Drug Metab. 2008;9(7):622-7.

Dzamko N, Gysbers A, Perera G, Bahar A, Shankar A, Gao J, et al. Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology. Acta Neuropathol (Berl). 2017;133(2):303-19.

Brailovskaia J. The "Vicious Circle of addictive Social Media Use and Mental Health" Model. Acta Psychol (Amst). 2024;247:104306.

Khanna S, Greeson JM. A Narrative Review of Yoga and Mindfulness as Complementary Therapies for Addiction. Complement Ther Med. 2013;21(3):244-52.

Eşkisu M, Çam Z, Gelibolu S, Rasmussen K. Trait Mindfulness as a Protective Factor in Connections between Psychological Issues and Facebook Addiction among Turkish University Students. Stud Psychol. 2020;62:213-31.

Sun X. A Review of Mindfulness and Social Media Excessive Use. Içinde Atlantis Press; 2022:1286-94.