Investigation of alexithymia in patients with functional dyspepsia

Authors

DOI:

https://doi.org/10.5281/zenodo.10001578

Keywords:

Alexithymia, Dysppepsia, Toronto alexithymia scale

Abstract

Objective: In psychometric test scales, patients with a diagnosis of FD have higher scores for anxiety, depression, and somatization than those without. Alexithymia is difficulty in expressing emotions and is closely related to psychosomatic diseases. In this study, we aimed to investigate the presence of alexithymia in patients with functional dyspepsia.

Material and methods: This study was conducted prospectively. Laboratory tests, ultrasonography and endoscopy were performed on the patients. TAS 20 questionnaire was applied to the patient and control groups. Statistical analyses were performed using SPPS v.27.0.

Results: A total of 80 subjects, 39 patients diagnosed with FD and 41 controls, were included in the study. The TAS-20 scale scores of the patient group were ≥61 in 13 (33.3%), 50-61 in 14 (35.9%), and below 50 in 12 (30.8%), with a mean of 56.2±11.3. In the control group, 1 (2.4%) was ≥61, 10 (24.4%) was between 50-61, 30 (73.2%) was below 50 and the mean was 46.2±5.9(p<0.001). TAS subscales were also significantly higher in the FD group.

Conclusions: Alexithymic personality structure should always be considered in patients diagnosed with FD. It can be explained to patients that the emotions they cannot express with words and behaviors are expressed in this way through the body. In this way, we believe that patients may give up their obsession with repeated endoscopies with the concern that I have an organic disease, and health care expenditures may be reduced.

References

Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, et al. Gastroduodenal Disorders. Gastroenterology. 2016;150(6):1380-92.

Talley NJ, Ford AC. Functional Dyspepsia. N Engl J Med. 2015;373(19):1853-63.

Talley NJ, Walker MM, Holtmann G. Functional dyspepsia. Curr Opin Gastroenterol. 2016;32(6):467-73.

Mahadeva S, Ford AC. Clinical and epidemiological differences in functional dyspepsia between the East and the West. Neurogastroenterol Motil. 2016;28(2):167-74.

Enck P, Azpiroz F, Boeckxstaens G, Elsenbruch S, Feinle-Bisset C, Holtmann G, et al. Functional dyspepsia. Nat Rev Dis Primers. 2017;3:17081.

Drossman DA, Creed FH, Olden KW, Svedlund J, Toner BB, Whitehead WE. Psychosocial aspects of the functional gastrointestinal disorders. Gut. 1999;45(II):II25- II30.

Aro P, Talley NJ, Johansson SE, Agréus L, Ronkainen J. Anxiety is linked to new-onset dyspepsia in the Swedish population: a 10-year follow-up study. Gastroenterology. 2015;148:928-37.

Sifneos PE. The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother Psychosom. 1973;22(2):255-62.

Taylor GJ, Bagby RM, Parker JD. The alexithymia construct. A potential paradigm for psychosomatic medicine. Psychosomatics. 1991;32(2):153-64.

Willemsen R, Roseeuw D, Vanderlinden J. Alexithymia and dermatology: the state of the art. Int J Dermatol. 2008;47(9):903-10.

Marchi L, Marzetti F, Orrù G, Lemmetti S, Miccoli M, Ciacchini R, et al. Alexithymia and Psychological Distress in Patients With Fibromyalgia and Rheumatic Disease. Front Psychol. 2019;10:1735.

Mazaheri M, Afshar H, Weinland S, Mohammadi N, Adibi P. Alexithymia and functional gastrointestinal disorders (FGID). Med Arh. 2012;66(1):28-32.

Taylor GJ, Parker JD, Bagby RM, Acklin MW. Alexithymia and somatic complaints in psychiatric out-patients. J Psychosom Res. 1992;36(5):417-24.

Taylor GJ, Bagby RM, Parker JD. The 20-Item Toronto Alexithymia Scale. IV. Reliability and factorial validity in different languages and cultures. J Psychosom Res. 2003;55(3):277-83.

Jonsson BH, Theorell T, Gotthard R. Symptoms and personality in patients with chronic functional dyspepsia. J Psychosom Res. 1995;39(1):93-102.

Wilhelmsen I. Somatization, sensitization, and functional dyspepsia. Scand J Psychol. 2002;43(2):177-80.

Talley NJ, Ford AC. Functional Dyspepsia. N Engl J Med. 2015;373(19):1853-63.

Patel P, Bercik P, Morgan DG, Bolino C, Pintos-Sanchez MI, Moayyedi P, et al. Irritable bowel syndrome is significantly associated with somatisation in 840 patients, which may drive bloating. Aliment Pharmacol Ther. 2015;41(5):449-58.

Vu J, Kushnir V, Cassell B, Gyawali CP, Sayuk GS. The impact of psychiatric and extraintestinal comorbidity on quality of life and bowel symptom burden in functional GI disorders. Neurogastroenterol Motil. 2014;26(9):1323-32.

Faramarzi M, Kheirkhah F, Shokri-Shirvani J, Mosavi S, Zarini S. Psychological factors in patients with peptic ulcerand functional dyspepsia. Caspian J Intern Med. 2014;5(2):71-6.

Portincasa P, Moschetta A, Baldassarre G, Altomare DF, Palasciano G. Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROME II criteria for irritable bowel syndrome. World J Gastroenterol. 2003;9(10):2293-9.

Porcelli P, Taylor GJ, Bagby RM, De Carne M. Alexithymia and functional gastrointestinal disorders. A comparison with inflammatory bowel disease. Psychother Psychosom. 1999;68(5):263-9.

Jones MP, Schettler A, Olden K, Crowell MD. Alexithymia and somatosensory amplification in functional dyspepsia. Psychosomatics. 2004;45(6):508-16.

Wise TN, Mann LS, Mitchell JD, Hryvniak M, Hill B. Secondary alexithymia: an empirical validation. Compr Psychiatry. 1990;31(4):284-8.

Kano M, Muratsubaki T, Yagihashi M, Morishita J, Mugikura S, Dupont P, et al. Insula Activity to Visceral Stimulation and Endocrine Stress Responses as Associated With Alexithymia in Patients With Irritable Bowel Syndrome. Psychosom Med. 2020;82(1):29-38.

Moriguchi Y, Decety J, Ohnishi T, Maeda M, Mori T, Nemoto K, et al. Empathy and judging other's pain: an fMRI study of alexithymia. Cereb Cortex. 2007;17(9):2223-34.

Drossman DA, Hasler WL. Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology. 2016;150(6):1257-61.

Kano M, Muratsubaki T, Van Oudenhove L, Morishita J, Yoshizawa M, Kohno K, et al. Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome. Sci Rep. 2017;7(1):12425.

Zheng PY, Feng BS, Oluwole C, Struiksma S, Chen X, Li P, et al. Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut. 2009;58(11):1473-9.

Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut. 2005;54(10):1481-91.

Kano M, Hamaguchi T, Itoh M, Yanai K, Fukudo S. Correlation between alexithymia and hypersensitivity to visceral stimulation in human. Pain. 2007;132(3):252-63.

Meddings JB, Swain MG. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology. 2000;119(4):1019-28.

Saunders PR, Santos J, Hanssen NP, Yates D, Groot JA, Perdue MH. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH. Dig Dis Sci. 2002;47(1):208-15.

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Published

2023-10-10

How to Cite

1.
Avci E, Aliyazicioglu M. Investigation of alexithymia in patients with functional dyspepsia. J Clin Trials Exp Investig [Internet]. 2023 Oct. 10 [cited 2024 Jul. 27];2(4):220-5. Available from: https://jctei.com/index.php/jctei/article/view/72