Three-Year Dentition Follow-up of a Paediatric Case with Malignant Infantile Osteopetrosis: A Review of the Literature

Ebru Akleyin; Yelda Polat; Yasemin Yavuz

doi:10.5281/zenodo.7088167

Authors

Ebru Akleyin Dicle University, Faculty of Dentistry, Department of Pediatric Dentistry, Diyarbakır, Turkey https://orcid.org/0000-0003-4302-6561
Yelda Polat Dicle University, Faculty of Dentistry, Department of Pediatric Dentistry, Diyarbakır, Turkey https://orcid.org/0000-0002-3228-3143
Yasemin Yavuz Harran University, Faculty of Dentistry, Department of Pediatric Dentistry, Şanlıurfa, Turkey https://orcid.org/0000-0001-5961-4996

DOI:

https://doi.org/10.5281/zenodo.7088167

Keywords:

Malignant infantile osteopetrosis, oral findings, tooth eruption disorders, paediatric dentistry

Abstract

Malignant infantile osteopetrosis (MIO), the most severe form of osteopetrosis, also known as marble bone disease, has a high rate of infant mortality and causes severe medical and dental outcomes in children. The general oral findings of this disease are reduced vascularisation of the jawbone as a result of impaired osteoclastic activity, eruption disorders, embedded teeth, missing teeth, dental hypoplasia and misshaping, excessive luxations associated with undeveloped roots, increased incidence of decay, and periodontal membrane defects. The current case patient was diagnosed with MIO at 4 months of age and underwent bone marrow transplantation at the age 3 years. The dentition development of the male patient was followed by regular dental examinations from the years 7 through 10. The tooth development of a MIO paediatric patient is presented in this case report with a review of the literature.

References

Albers-Schönberg HE. Röntgenbilder einer seltenen knochenerkrankung. Munch Med Wochenschr. 1904; 51:365–68.

Loría-Cortés R, Quesada-Calvo E, Cordero-Chaverri C. Osteopetrosis in children: a report of 26 cases. J Pediatr. 1977 Jul;91[1]:43-7.

Beighton P, Horan F, Hamersma H. A review of the osteopetroses. Postgrad Med J. 1977 Aug;53[622]:507-16.

de Baat P, Heijboer MP, de Baat C. [Osteopetrosis. Classification, etiology, treatment options and implications for oral health]. Ned Tijdschr Tandheelkd. 2005 Dec;112[12]:497-503.

Stoker DJ. Osteopetrosis. Semin Musculoskelet Radiol 2002; 4: 299-305.

Wilson CJ, Vellodi A. Autosomal recessive osteopetrosis: diagnosis, management and out come. Arch Dis Child 2000; 83: 449-52.

Schwartz SI, ed. Principles of surgery. 6th ed. New York, McGraw Hill, Health Professions Division, 1994: 1893–94.

Wyngaarden JB, Smith LH Jr, Bennett JC, eds. Cecil textbook of medicine. 20th ed. Philadelphia, Saunders, 1996: 1388–89.

Imani MM, Davachi B, Nemati S, Jouharı M. Dental radiographic findings of malignant osteopetrosis: Report of four cases. Iran J Radiol 2009; 6[3].

Crotkett DM, Stanley RB, Lubka R. Osteopetrosis and dental findings. Osteomyelitis of the maxilla in a patient with osteopetrosis [Albers-Schönberg disease]. Otolaryngol Head Neck Surg 1986; 95[1]: 117-21.

Symons AL, Powell RN, Seymour GJ, Harbrow DJ. Disturbances of tooth form and eruption in the microphthalmic [mi] mouse: a light and electron microscopic study. Arch Oral Biology 1989; 34[2]: 71-76.

Younai F, Eisenbud L, Sciubba JJ. Osteopetrosis: a case report including gross and microscopic findings in the mandible at autopsy. Oral Surg Oral Med Oral Pathol 1988; 65[2]: 214-21.

Friede H, Manaligod JR, Rosenthal IM. Craniofacial abnormalities in osteopetrosis with precocious manifestations: report of a case with serial cephalometric roentgenograms. J Craniofac Genet Dev Biol 1985; 5[3]: 247-57.

Phillippart C, Arys A, Dourov N. Histopathology of the interactions between alveolar bone and impacted dental germs in osteopetrotic op/op rats. J Oral Pathol Med 1989; 18[3]: 157-62.

Droz‐Desprez D, Azou C, Bordigoni P, Bonnaure‐Mallet M. Infantile osteopetrosis: a case report on dental findings. J Oral Pathol Med 1992; 1[9]: 422- 25.

Jälevik B, Fasth A, Dahllöf G. Dental development after successful treatment of infantile osteopetrosis with bone marrow transplantation. Bone Marrow Transplant 2002; 29[6]: 537-40.

Bjorvatn K, Gılhuus‐Moe O, Aarskog D. Oral aspects of osteopetrosis. Scand J Dent Res 1979; 87[4] : 245-52.

Dick HM, Sımpson WJ [1972] . Dental changes in osteopetrosis. Oral Surg Oral Med Oral Pathol 34 [3]: 408- 416.

Lam DK, Sándor GK, Holmes HI, Carmichael RP, Clokie CM. A Review of Osteopetrosis and Its Oral Health Implications for Dentists David. J Can Dent Assoc 2007; 73[9]: 417.

Bedi RS, Goel P, Pasricha N, Goel A. Osteopetrosis-A rare entity with osteomyelitis. Ann Maxillofac Surg 2011; 1[2]: 155-59.

Allal S, Rabuel V, Gengler C, Douchet C, Allal F, Zwetyenga N. Case report of osteomyelitis of the mandible in osteopetrosis and management considerations. Int J Surg Case Rep 2021; 81: 105813.