Overview of current fluorine-free remineralization materials and methods as an alternative to topical fluoride: An up-to-date

Authors

DOI:

https://doi.org/10.5281/zenodo.7359788

Keywords:

Dental caries, fluorine-free materials, remineralization

Abstract

Dental caries is a common public health problem around the world, and it has been aimed to solve this health problem with many different materials and methods from the past to the present. With the demineralization process occurring in the tooth’s hard tissues, mineral loss occurs and initial caries lesions and cavitations due to caries occur. On the other hand, the remineralization process can be defined as the removal of existing minerals and hard tissue loss with ions in saliva, newly developed or existing materials,s and methods. The success of fluoride in remineralization has been proven by many literature data and is accepted as the gold standard. Although the use of fluoride in preventive dentistry is the gold standard; Due to the possible side effects and the refusal of fluoride by parents and healthcare professionals, researchers have sought new remineralization materials and methods that can provide remineralization, increase the effectiveness of fluoride or be an alternative to fluoride, with the aim of reducing the fluoride concentrations used. In clinical applications, as an alternative to flora, mineral and ion technologies, sugar alcohols, plant-derived products, bioactive materials, nanotechnological products, calcium, and phosphate-derived other products contribute to the remineralization process and are among the current remineralization materials and methods. In this review, up-to-date information on fluorine-free remineralization materials, mechanisms of action, and clinical applications of new methods and technologies were examined in order to evaluate them in line with the results of scientific studies, and it was aimed to present the studies on this subject.

References

Yon MJY, Gao SS, Chen KJ, Duangthip D, Lo ECM, Chu CH. Medical Model in Caries Management. Dent J (Basel). 2019;7(2):37.

Reich E, Lussi A, Newbrun E. Caries‐risk assessment. Int Dent J. 1999;49(1):15-26.

Hemagaran G, Neelakantan P. Remineralization of the tooth structure – the future of dentistry. IJPRIF. 2014;6(2):487-93.

Peng JJY, Botelho MG, Matinlinna JP. Silver compounds used in dentistry for caries management: A review. J Dent. 2012;40(7):531-41.

Rosenblatt A, Stamfort TCM, Niederman R. Silver diamine Fluoride (SDF) may be better than fluoride varnish and no treatment in arresting and preventing cavitated carious lesions. J Dent. 2009;88(8):116-25.

Alves KMRP, Franco KS, Sassaki KT, Buzalaf MAR, Delbem ACB. Effect of iron on enamel demineralization and remineralization in vitro. Arch Oral Biol. 2011;56(11):1192-8.

Horst JA, Tanzer JM, Milgrom PM. Fluorides and Other Preventive Strategies for Tooth Decay. Dent Clin North Am. 2018;62(2):207-34.

Makinen KK, Saag M, Isotupa KP, Olak J, Nõmmela R, Söderling E, et al. Similarity of the effects of erythritol and xylitol on some risk factors of dental caries. Caries Res. 2005;39(3):207–15.

Seppä L. Fluoride varnishes in caries prevention. Med Princ Pract. 2004;13(6):307-11.

Makinen KK. Sugar alcohols, caries incidence and remineralization of caries lesions:a literature review. Int J Dent. 2010;2010:981072.

Hayes ML, Roberts KR. The breakdown of glucose, xylitol and other sugar alcohols by human dental plaque bacteria. Arch Oral Biol. 1978;23(6):445–51.

Featherstone JD, Rodgers BE, Smith MW. Physicochemical requirements for rapid remineralization of early carious lesions. Caries Res. 1981;15(3):221-35.

Takatsuka T, Exterkate RA, ten Cate JM. Effects of Isomalt on enamel de- and remineralization, a combined in vitro pH-cycling model and in situ study. Clin Oral Investig. 2008;12(2):173-7.

Shıbasaki K, Sano H, Matsukubo T, Takaesu Y. Effects of low molecular chitosan on pH changes in human dental plaque. Bull Tokyo Dent Coll. 1994;35(1):33–9.

Arnaud TM, de Barros Neto B, Diniz FB.Chitosan effect on dental enamel de-remineralization: an in vitro evaluation. J Dent. 2010;38(11):848-52.

Islam SM, Hiraishi N, Nassar M, Sono R, Otsuki M, Takatsura T, et al. In vitro effect of hesperidin on root dentin collagen and de/re-mineralization. Dent Mater J. 2012;31(3):362-67.

Perumalla AVS, Hettiarachchy NS. Green tea and grape seed extracts - Potential applications in food safety and quality. Food Res Int. 2011;44(4):827-39.

Benjamin S, Sharma R, Thomas SS, Nainan MT. Grape seed extract as a potential remineralizing agent: a comparative in vitro study. J Contemp Dent Pract. 2012;13(4):425-30.

Nagi S, Hassan S, Abd El-Alim S, Elmissiry M. Remineralization potential of grape seed extract hydrogels on bleached enamel compared to fluoride gel: An in vitro study. J Clin Exp Dent. 2019;11(5):e401-e407.

Cheng L, Ten Cate JM. Effect of Galla chinensis on the in vitro remineralization of advanced enamel lesions. Int J Oral Sci. 2010;2:15-20

Chu JP, Li JY, Hao YQ, Zhou XD. Effect of compounds of Galla Chinensis on remineralization of initial enamel carious lesions in vitro. J Dent. 2007;35(5):383-7.

Xie Q, Li JY, Zuo YL, Zhou XD. The effect of Galla chinensis on the growth of cariogenic bacteria in vitro. Hua Xi Kou Qiang Yi Xue Za Zhi. 2005;23(1):82-4.

George D, Bhat SS, Antony B. Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in vitro study. Gen Dent. 2009;57(3):238-41.

Amaechi BT, Porteous N, Ramalingam K, Mensinkai PK, Ccahuana Vasquez RA, Sadeghpour A, et al. Remineralization of artificial enamel lesions by theobromine. Caries Res. 2013;47(5):399-405

Burdock GA. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 1998;36(4):347-63.

Duailibe SA de C, Gonçalves AG, Ahid FJM. Effect of a propolis extract on Streptococcus mutans counts in vivo. J Appl Oral Sci. 2007;15(5):420-3.

Park M, Bae J, Lee DS. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res. 2008;22(11):1446-9.

Trindade Grégio AM, Miyamoto Fortes ES, Ribeiro Rosa EA, Baggio Simeoni R, Takaki Rosa R. Antimicrobial Activity from Zingiber Officinalle on Oral Cavity Pathogens. Estudos de Biologica. 2006;28(62):61-6.

Moreno S, Scheyer T, Romano CS, Vojnov AA. Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic Res. 2006;40(2):223-31.

Akan H, Balos M. GAP Bölgesinden toplanan meyan kökü (Glycrrhiza glabra L.) taksonunun ihracat durumu, etnobotanik özellikleri ve tıbbi önemi. Fırat Üniv Fen ve Mühendislik Bilimleri Derg. 2008;20(2):233-41.

Sela MN, Steinberg D, Segal R. Inhibition of the activity of glucosyltransferase from Streptococcus mutans by glycyrrhizin. Oral Microbiol Immunol. 1987;2(3):125-8.

Haghgoo R, Ahmadvand M, Moshaverinia S. Remineralizing effect of topical NovaMin and nano-hydroxyapatite on caries-like lesions in primary teeth. J Contemp Dent Pract. 2016;17(8):645-9.

Ergin E, Eden E. Mine lezyonlarının farklı ajanlarla remineralizasyonu. Turkiye Klinikleri J Pediatr Dent-Special Topics. 2015;1(3):57- 64.

Ceyhan T, Günay V, Capoğlu A, Sayrak H, Karaca C. Production and characterization of a glass-ceramic biomaterial and in vitro and in vivo evaluation of its biological effects. Acta Orthop Traumatol Turc. 2007;41(4):307-13.

Dong Z, Chang J, Deng Y, Joiner A. Tricalcium silicate induced mineralization for occlusion of dentinal tubules. Aust Dent J. 2011;56(2):175-80.

Huang SB, Gao SS, Yu HY. Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro. Biomed Mater. 2009;4(3):034104.

Yamagishi K, Onuma K, Suzuki T, Okada F, Tagami J, Otsuki M, et al. Materials chemistry: a synthetic enamel for rapid tooth repair. Nature. 2005;433(7028):819.

Zhao J, Liu Y, Sun WB, Zhang H. Amorphous calcium phosphate and its application in dentistry. Chem Cent J. 2011;5:40.

de Pinto Sinfiteli P, Coutinho TCL, de Oliveira PRA, Vasques WF, Azevedo LM, Pereira AMB, et al. Effect of fluoride dentifrice and casein phosphopeptide-amorphous calcium phosphate cream with and without fluoride in preventing enamel demineralization in a pH cyclic study. J Appl Oral Sci. 2017;25(6):604- 11.

Çetin B, Avşar A, Ulusoy AT. Kazein içerikli besinler ve dental ürünler. Atatürk Üniv Diş Hek Fak Derg. 2011;2011(4):24-31.

Sudjalim TR, Woods MG, Manton DJ. Prevention of white spot lesions in orthodontic practice: a contemporary review. Aust Dent J. 2006;51(4):284-9.

Reynolds EC, Cai F, Shen P, Walker GD. Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res. 2003;82(3):206-11.

Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. J Dent. 2007;35(8):695-8.

Cochrane NJ, Saranathan S, Cai F, Cross KJ, Reynolds EJ. Enamel subsurface remineralization with casein phosphopeptides stabilized solution of calcium, phosphate and fluorid. Caries Res. 2008;42(2):88-97

Vogel GL, Zhang Z, Carey CM, Ly A, Chow LC, Proskin HM. Composition of plaque and saliva following a sucrose challenge and use of an alpha tricalcium-phosphate-containing chewing gum. J Dent Res. 1998;77(3):518-24.

Brunton PA, Davies RPW, Burke JL, Smith A, Aggeli A, Brookes SJ, et al. Treatment of early caries lesions using biomimetic self-assembling peptides - a clinical safety trial. Br Dent J. 2013;215(4):E6.

Alkilzy M, Santamaria RM, Schmoeckel J, Splieth CH. Treatment of carious lesions using self-assembling peptides. Adv Dent Res. 2018;29(1):42-7.

Ruan Q, Moradian-Oldak J. Amelogenin and enamel biomimetics. J Mater Chem B. 2015;3(16):3112-29.

Fan Y, Sun Z, Moradian-Oldak J. Controlled remineralization of enamel in the presence of amelogenin and fluoride. Biomaterials. 2009;30(4):478-83.

Yarbrough DK, Hagerman E, Eckert R, He J, Choi H, Cao N, et al. Specific binding and mineralization of calcified surfaces by small peptides. Calcif Tissue Int. 2010;86(1):58-66.

Hsu CC, Chung HY, Yang J-M, Shi W, Wu B. Influence of 8DSS Peptide on Nano-mechanical Behavior of Human Enamel. J Dent Res. 2011;90(1):88-92.

Nijhuis AW, Nejadnik MR, Nudelman F, Walboomers XF, Riet J, Habibovic P, et al. Enzymatic pH control for biomimetic deposition of calcium phosphate coatings, Acta Biomater. 2014;10(2):931-9.

Gu LS, Kim YK, Liu Y, Takahashi K, Arun S, Wimmer CE, et al. Immobilization of a phosphonated analog of matrix phosphoproteins within cross-linked collagen as a templating mechanism for biomimetic mineralization. Acta Biomater. 2011;7(1):268-77.

Cao CY, Mei ML, Li QL, Lo EC, Chu CH. Methods for biomimetic remineralization of human dentine: a systematic review. Int J Mol Sci. 2015;16(3):4615-27.

Ning TY, Xu XH, Zhu LF, Zhu XP, Chu CH, Liu LK, et al. Biomimetic mineralization of dentin induced by agarose gel loaded with calcium phosphate, J Biomed Mater Res B Appl Biomater. 2012;100(1):138-44.

Chen J, Cao X, Guo R, Shen M, Peng C, Xiao T, et al. A highly effective polymerase chain reaction enhancer based on dendrimer-entrapped gold nanoparticles. Analyst. 2012;137(1):223-8.

Sun M, Wu N, Chen H. Laser-assisted Rapid Mineralization of Human Tooth Enamel. Sci Rep. 2017;7(1):9611.

Sullivan RJ, Charig A, Blake-Haskins J, Zhang YP, Miller SM, Strannick M, et al. In vivo detection of calcium from dicalcium phosphate dihydrate dentifrices in demineralized human enamel and plaque. Adv Dent Res. 1997;11(4):380-7.

Zhang YP, Din CS, Miller S, Nathoo SA, Gaffar A. Intraoral remineralization of enamel with a MFP/DCPD and MFP/ silica dentifrice using surface microhardness. J Clin Dent 1995;6(2):148-53.

Kitasako Y, Tanaka M, Sadr A, Hamba H, Ikeda M, Tagami J. Effects of a chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and fluoride on remineralization and crystallization of enamel subsurface lesions in situ. J Dent 2011;39(11):771-9.

To-o K, Kamasaka H, Nishimura T, Kuriki T, Saeki S,Nakabou Y. Absorbability of calcium from calcium-bound phosphoryl oligosaccharides in comparison with that from various calcium compounds in the rat ligated jejunum loop. Biosci Biotechnol Biochem. 2003;67(8):1713-8.

Cury JA, Simões GS, Del Bel Cury AA, Gonçalves NC, Tabchoury CPM. Effect of a calcium carbonate-based dentifrice on in situ enamel remineralization. Caries Res. 2005;39(3):255-7.

Danelon M, Takeshita EM, Sassaki KT, Delbem AC. In situ evaluation of a low fluoride concentration gel with sodium trimetaphosphate in enamel remineralization. Am J Dent. 2013;26:15-20.

Grenby TH. Trials of 3 organic phosphorus containing compounds as protective agents against dental caries in rats. J Dent Res. 1973;52(3):454-61

Sezer B, Tuğcu N, Durmus B, Bekiroglu N, Kargula B. Efficacy of mineral containing gel for remineralization in MIH-affected incisors: a 3-months clinical study. 64th ORCA Congress. Caries Res. 2017;51:362.

Perkin KK, Turner JL, Wooley KL, Mann S. Fabrication of hybrid nanocapsules by calcium phosphate mineralization of shell cross-linked polymer micelles and nanocages. Nano Lett. 2005;5(7):1457-61.

Shibata Y, Yamamoto H, Miyazaki T. Colloidal beta-tricalcium phosphate prepared by discharge in a modified body fluid facilitates synthesis of collagen composites. J Dent Res. 2005;84(9):827-31.

Kim D-S, Kim J, Choi K-K, Kim S-Y. The influence of chlorhexidine on the remineralization of demineralized dentine. J Dent. 2011;39(12):855-62.

De Munck J, Van den Steen PE, Mine A, Van Landuyt KL, Poitevin A, Opdenakker G, et al. Inhibition of enzymatic degradation of adhesive-dentin interfaces. J Dent Res. 2009;88(12):1101-6.

Schweizer HP. Triclosan: a widely used biocide and its link to antibiotics. FEMS Microbiol Lett. 2001;202(1):1-7

Silva MFDA, Giniger MS, Zhang YP, Devizio W. The effect of a triclosan/copolymer/fluoride liquid dentifrice on interproximal enamel remineralization and fluoride uptake. J Am Dent Assoc. 2004;135(7):1023-9.

Ástvaldsdóttir Á, Naimi-Akbar A, Davidson T, Brolund A, Lintamo L, Attergren Granath A, et al. Arginine and Caries Prevention: A Systematic Review. Caries Res. 2016;50(4):383-93.

Poosti M, Ahrari F, Moosavi H, Najjaran H. The effect of fractional CO2 laser irradiation on remineralization of enamel white spot lesions. Lasers Med Sci. 2014;29(4):1349-55.

Tandan M, Gupta S, Tandan P. Ozone in Conservative Dentistry & Endodontics: A Review. Int J Clin Prev Dent. 2012;8(1):29-35.

Pitts NB, Wright JP. Reminova and EAER: Keeping Enamel Whole through Caries Remineralization. Adv Dent Res. 2018;29(1):48-54.

Akleyin E, Polat Y, Yavuz Y. Three-Year Dentition Follow-up of a Paediatric Case with Malignant Infantile Osteopetrosis: A Review of the Literature. J Clin Tri Exp Invest. 2022;1(2):41-8.

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Published

2022-11-26

How to Cite

1.
Polat Y, Çelenk S. Overview of current fluorine-free remineralization materials and methods as an alternative to topical fluoride: An up-to-date. J Clin Trials Exp Investig [Internet]. 2022 Nov. 26 [cited 2024 Mar. 29];1(3):75-8. Available from: https://jctei.com/index.php/jctei/article/view/31